IL-33 Recombinant Protein
Product Specifications
Background
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3) /ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
NCBI Gene ID
77125
Swiss Prot
O95760
Accession Number
Q2YEJ4
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Innate Immunity
Buffer
0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Shipping Conditions
Blue Ice
Storage Conditions
Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-047
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Interleukin 33
NCBI Organism
Mus musculus
Other Product Names
Interleukin-33, IL-1F11, NF-HEV
Species
Human, Mouse
Protein ID
68565902
Physical Properties
Liquid
CAS Number
9000-83-3
Curated Selection
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