IL18 BP Recombinant Protein
Product Specifications
Background
Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
CAS Number
9000-83-3
NCBI Gene ID
10068
Swiss Prot
O95998
Accession Number
NP_001138529
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
44.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Interleukin 18 binding protein
NCBI Organism
Homo sapiens
Background Reference 01
Novick D., et al., 1999, Immunity 10:127-136.
Background Reference 02
Aizawa Y., et al., 1999, FEBS Lett. 445:338-342.
Background Reference 03
Halim A., et al., 2011, Mol. Cell. Proteomics 0:0-0.
Other Product Names
IL18BP, IL18BPa, Tadekinig-alfa
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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