IL-17 RE (155-454) Recombinant Protein
Product Specifications
Background
Interleukin-17 receptor E (IL-17 RE) is an orphan receptor of the IL-17 receptor family, also known as UNQ3056, PRO9877, IL-17 Receptor E. IL-17RE is known to be expressed in the pancreas, brain, and prostate. IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C functioned in a unique autocrine manner, binding to a receptor complex consisting of the receptors IL-17RA and IL-17RE, which was preferentially expressed on tissue epithelial cells. Some data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
CAS Number
9000-83-3
NCBI Gene ID
132014
Swiss Prot
Q8NFR9
Accession Number
NP_705613.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
60.5 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.5 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Interleukin17receptorE
NCBI Organism
Homo sapiens
Background Reference 01
Song X. Nat Immunol. 2011. 12 (12) :1151-8.
Background Reference 02
Ramirez-Carrozzi V. Nat Immunol. 2011. 12 (12) :1159-66.
Background Reference 03
Pfeifer P. Am J Respir Cell Mol Biol. 2013. 48 (4) :415-21.
Other Product Names
IL-17 RE, IL17RE, IL-17RE, IL-17 receptor E
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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