IL-12 R beta1 Recombinant Protein
Product Specifications
Background
Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.
NCBI Gene ID
3594
Swiss Prot
P42701
Accession Number
P42701
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Chemokines & Cytokines, Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-544
Calculated Molecular Weight
84.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Interleukin 12 receptor subunit beta 1
NCBI Organism
Homo sapiens
Other Product Names
CD212, IL12RB1, CD212 antigen, IL-12 receptor beta component, IL-12 receptor subunit beta-1, IL12R; IL-12R subunit beta-1, IL12RB, IL-12RB1, IL-12R-BETA1, IL-12R-beta-1, interleukin-12 receptor beta-1 chain, interleukin-12 receptor subunit beta-1
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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