IL-12 Recombinant Protein
Product Specifications
Background
Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumor and anti viral agent.
NCBI Gene ID
3593
Swiss Prot
Q5FW60
Accession Number
NP_002178/ NP_000873
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Cancer, Immunology, Infectious Disease, Innate Immunity, Signal Transduction
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-502
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Interleukin 12B
NCBI Organism
Homo sapiens
Other Product Names
Interleukin-12, IL-12p70, IL-12p75, Cytotoxic Lymphocyte Maturation Factor, CLMF, NKSF, Natural Killer Cell Stimulatory Factor, TSF, T-cell Stimulatory Factor
Species
Human
Protein ID
24497438
Physical Properties
Lyophilized
CAS Number
9000-83-3
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