IL 1 R2 Recombinant Protein
Product Specifications
Background
Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB) . IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
NCBI Gene ID
7850
Swiss Prot
P27930
Accession Number
NP_004624.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Chemokines & Cytokines, Immunology, Obesity, Signal Transduction, Stem Cell
Purity
>98% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-436
Calculated Molecular Weight
38.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Interleukin 1 receptor, type II
NCBI Organism
Homo sapiens
Background Reference 01
Liu C., et al., 1996, J. Biol. Chem. 271:20965-20972.
Background Reference 02
Giri J.G., et al., 1994, J. Immunol. 153:5802-5809.
Background Reference 03
Symons J.A., et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718.
Background Reference 04
Orlando S., et al., 1997, J. Biol. Chem. 272:31764-31769.
Other Product Names
CD121b, IL1RB, IL1R2, CDw121b
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
