IL-6 Recombinant Protein
Product Specifications
Background
Interleukin 6 (IL-6) is also known as HGF, BSF2, HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts, endothelial cells, et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer's Disease, systemic, lupus erythematosus, prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
NCBI Gene ID
16193
Swiss Prot
P08505
Accession Number
NP_112445.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Chemokines & Cytokines, Immunology, Neuroscience, Obesity, Signal Transduction
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-126
Calculated Molecular Weight
23.6 kDa
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 23.6 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Interleukin6
NCBI Organism
Mus musculus
Background Reference 01
Ferguson-Smith AC, et.al. 1988, Genomics 2 (3) : 203–8.
Background Reference 02
Schwantner A, et. al. 2004, J. Biol. Chem. 279 (1) : 571–6.
Background Reference 03
Schuster B, et. al. 2003, J. Biol. Chem. 278 (11) : 9528–35.
Background Reference 04
Taga T, et al.1989, Cell 58 (3) : 573–81.
Other Product Names
IL6, Interleukin-6, BSF2, HSF, IFNB2
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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