IL-18 binding protein d Recombinant Protein
Product Specifications
Background
Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF- gamma , which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig) -like C2-type domain which is essential to the binding and neutralizing properties of the binding proteins. The IL-18 BP isoforms b and d lack a complete Ig domain. The expression of IL-18 and the IL-18BP are indentified in immune tissues such as the spleen, but also in nonimmune cells including keratinocytes.
NCBI Gene ID
16068
Swiss Prot
Q9Z0M9
Accession Number
Q9Z0M9
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Chemokines & Cytokines, Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-637
Calculated Molecular Weight
45.1 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Interleukin 18 binding protein
NCBI Organism
Mus musculus
Other Product Names
Interleukin 18 Binding Protein Isoform d, IL-18 BPd
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
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