ITM2B Recombinant Protein
Product Specifications
Background
Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1 (CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2 (CAA-ITM2B2) . CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.
NCBI Gene ID
9445
Swiss Prot
Q9Y287
Accession Number
Q9Y287
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Apoptosis, Neuroscience
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-567
Calculated Molecular Weight
23.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Integral membrane protein 2B
NCBI Organism
Homo sapiens
Other Product Names
Integral Membrane Protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane Protein BRI, Bri, ITM2B, BRI2
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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