IGFBP-4 Recombinant Protein
Product Specifications
Background
Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.
NCBI Gene ID
3487
Swiss Prot
NP_001543.2
Accession Number
AAH16041
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-890
Calculated Molecular Weight
27.9 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Insulin-like growth factor binding protein 4
NCBI Organism
Homo sapiens
Background Reference 01
Tagliabracci V.S., et al., 2015, Cell 161:1619-1632.
Background Reference 02
Culouscou J.M., et al.,1991, Cancer Res. 51:2813-2819.
Other Product Names
IGFBP4, IBP-4
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
