ICOS / CD278 (C137S, C138S) Recombinant Protein
Product Specifications
Background
Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
NCBI Gene ID
54167
Swiss Prot
Q9WVS0
Accession Number
NP_059508.2 (C137S, C138S)
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-312
Calculated Molecular Weight
40.6 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Inducible T cell co-stimulator
NCBI Organism
Mus musculus
Background Reference 01
Hutloff A., et al., 1999, Nature 397:263-266.
Background Reference 02
Tezuka K., et al., 2000, Biochem. Biophys. Res. Commun. 276:335-345.
Background Reference 03
Beier K.C., et al., 2000, Eur. J. Immunol. 30:3707-3717.
Other Product Names
ICOS, CD278, AILIM, Inducible T-cell costimulator
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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