IgG2a Fc Region Recombinant Protein
Product Specifications
Background
Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F (ab) s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis.
NCBI Gene ID
380793
Swiss Prot
P01863.1
Accession Number
CAC20702
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM tris, 100 mM glycine, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-421
Calculated Molecular Weight
26.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Immunoglobulin heavy constant gamma 2A
NCBI Organism
Mus musculus
Background Reference 01
Sikorav J.-L., et al., 1980, Nucleic Acids Res. 8:3143-3155.
Background Reference 02
Ollo R., et al., 1981, Proc. Natl. Acad. Sci. U.S.A. 78:2442-2446.
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
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