IL-4 R alpha / CD124 Recombinant Protein
Product Specifications
Background
IL-4 R alpha is also known as IL4R, CD124, IL-4RA.This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Interleukin-4 receptor has been shown to interact with SHC1.
NCBI Gene ID
3566
Swiss Prot
P24394
Accession Number
NP_000409.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-393
Calculated Molecular Weight
50.4 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Interleukin 4 receptor
NCBI Organism
Homo sapiens
Background Reference 01
Tundup S., 2012, Ann. N. Y. Acad. Sci., 1253: E1–E13.
Background Reference 02
Ikizawa K, Yanagihara Y., 2000, Biochem. Biophys. Res. Commun., 268 (1) : 54–9.
Background Reference 03
Kashiwada M., 2001, J. Immunol., 167 (11) : 6382–7.
Other Product Names
IL4R, CD124, IL4RA
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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