IL-36Ra Recombinant Protein

Product Specifications

Background

IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) . These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.

CAS Number

9000-83-3

NCBI Gene ID

54450

Swiss Prot

Q9Y275

Accession Number

Q9QYY1

Tag

Tag Free

Type

Recombinant Proteins

Source

E. coli

Field of Research

Chemokines & Cytokines

Concentration

0.1mg/ml after reconstitution.

Buffer

Contains PBS. Reconstitute with 100 μ l sterile water.

Shipping Conditions

Room Temp

Storage Conditions

Stable for at least 6 months after receipt when stored at -20˚ C.

Applications Notes

This recombinant proteins is for research use only.

NCBI Official Name

Interleukin 1 family, member 5 (delta)

NCBI Organism

Mus musculus

Other Product Names

Interleukin-36 Receptor Antagonist Protein, IL-1F5, Interleukin-1 Family Member 5, IL-1delta, Interleukin-1delta, Interleukin-1 Homolog 3, Interleukin-1-like Protein 1