IL-36beta Recombinant Protein
Product Specifications
Background
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
CAS Number
9000-83-3
NCBI Gene ID
27177
Swiss Prot
Q9JJN1
Accession Number
Q9NZH7
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Immunology
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS + 0.5% trehalose. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Interleukin 36, beta
NCBI Organism
Homo sapiens
Other Product Names
Interleukin-36beta, Interleukin-1 Family Member 8, IL-1F8
Species
Human
Protein ID
20070252
Physical Properties
Lyophilized
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