IDO Recombinant Protein
Product Specifications
Background
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
NCBI Gene ID
15930
Swiss Prot
Q8K3R4
Accession Number
P28776
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Immunology, Innate Immunity, Obesity
Concentration
1mg/ml
Buffer
0.2um-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA.
Shipping Conditions
Blue Ice
Storage Conditions
Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-017
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Indoleamine 2,3-dioxygenase 1
NCBI Organism
Mus musculus
Other Product Names
Indoleamine 2,3-dioxygenase, INDO
Species
Mouse
Protein ID
123949
Physical Properties
Liquid
CAS Number
9000-83-3
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