IDO Recombinant Protein
Product Specifications
Background
IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
CAS Number
9000-83-3
NCBI Gene ID
15930
Swiss Prot
Q8K3R4
Accession Number
P28776
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Immunology, Innate Immunity, Obesity
Concentration
1mg/ml
Buffer
0.2um-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA.
Shipping Conditions
Blue Ice
Storage Conditions
Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Indoleamine 2,3-dioxygenase 1
NCBI Organism
Mus musculus
Other Product Names
Indoleamine 2,3-dioxygenase, INDO
Species
Mouse
Protein ID
123949
Physical Properties
Liquid
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