NEDD8 Recombinant Protein
Product Specifications
Background
Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.
CAS Number
9000-83-3
NCBI Gene ID
4738
Swiss Prot
Q15843
Accession Number
Q15843
Tag
N-6 His, SUMO tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
20.9 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Neural precursor cell expressed, developmentally down-regulated 8
NCBI Organism
Homo sapiens
Other Product Names
Neural precursor cell expressed developmentally down-regulated protein 8, NEDD8, Neddylin, Ubiquitin-like protein Nedd8
Species
Human
Physical Properties
Lyophilized
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