EGF Recombinant Protein
Product Specifications
Background
Human epidermal growth factor (EGF) is also known as HOMG4 and URG, and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. All family members contain one or more repeats of the conserved amino acid sequence. The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents. Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.
NCBI Gene ID
13645
Swiss Prot
P01132
Accession Number
NP_034243.2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-373
Calculated Molecular Weight
32.5 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 32.5 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Epidermal growth factor
NCBI Organism
Mus musculus
Background Reference 01
Barnham KJ, et al. 1998, Protein Science 7 (8) : 1738–49.
Background Reference 02
Cotran, Ramzi S., et al. 2005, Robbins and Cotran pathologic basis of disease.
Background Reference 03
Dreux AC, et al. 2006, Atherosclerosis 186 (1) : 38–53.
Background Reference 04
Venturi S, et al.2009, Nutrition and Health 20 (2) : 119–134.
Other Product Names
EGF, URG, HOMG4
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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