B7-H3 (4Ig) / B7-H3b Recombinant Protein
Product Specifications
Background
Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V‑like and Ig C‑like domains with a short cytoplasmic tail. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V‑type and one C‑type) and shows a ubiquituous expression pattern.
NCBI Gene ID
80381
Swiss Prot
Q5ZPR3
Accession Number
NP_001019907.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-422
Calculated Molecular Weight
48.5 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD276 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Chapoval AI., et al. 2001, Nat Immunol., 2 (3), 269-74.
Background Reference 02
Steinberger P., et al. 2004, J Immunol., 172 (4), 2352-9.
Background Reference 03
Sun M., et al. 2002, J Immunol., 168 (12), 6294-7.
Other Product Names
4Ig-B7-H3, B7-H3, CD276, PSEC0249, UNQ309/PRO352, B7 homolog 3
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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