HMGB1 Recombinant Protein
Product Specifications
Background
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
CAS Number
9000-83-3
NCBI Gene ID
25459
Swiss Prot
Q14116
Accession Number
NP_037095
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
High mobility group box 1
NCBI Organism
Rattus norvegicus
Other Product Names
High Mobility Group Protein B1
Species
Rat
Protein ID
6981026
Physical Properties
Lyophilized
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