HTRA2 Recombinant Protein

Product Specifications

Background

High temperature requirement protein A2 (HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by IAP caspase inhibitors such as XIAP and CIAP1/2. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. The protein cleaves THAP5 and promotes its degradation during apoptosis.

CAS Number

9000-83-3

NCBI Gene ID

27429

Swiss Prot

O43464

Accession Number

O43464

Tag

C-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Apoptosis, Immunology

Buffer

Supplied as a 0.2 um filtered solution of 20mM Tris,150mM NaCl, pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

Shipping Conditions

Dry Ice

Calculated Molecular Weight

36 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

HtrA serine peptidase 2

NCBI Organism

Homo sapiens

Other Product Names

Serine protease HTRA2, mitochondrial, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, OMI, PRSS25