High Mobility Group Protein B1 Recombinant Protein
Product Specifications
Background
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses.
CAS Number
9000-83-3
NCBI Gene ID
3146
Swiss Prot
P09429
Accession Number
P09429
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Innate Immunity, Other
Buffer
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, 1mM DTT, 10% Glycerol, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-328
Calculated Molecular Weight
25.93 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
High mobility group box 1
NCBI Organism
Homo sapiens
Other Product Names
High Mobility Group Protein B1, High Mobility Group Protein 1, HMG-1, HMGB1, HMG1
Species
Human
Physical Properties
Liquid
Curated Selection
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