FGF1 Recombinant Protein
Product Specifications
Background
Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF acidic is a potent growth factor for fibroblasts and endothelial cells. FGF acidic is involved in wound repair, angiogenesis, and development. FGF acidic is secreted from cells via an endoplasmic reticulum/Golgi independent mechanism. The ability of FGF acidic to bind to heparin sulfate is required for its ability to interact with FGF receptors and induce signaling. There are four distinct FGF receptors and each has multiple splice variants. FGF acidic binds with high affinity to many, but not all, FGFRs. Signaling cascades activated through FGF basic binding to FGFR include the ras-raf-MAPK, PLCγ/PKC, and PI3K/Akt pathways.
CAS Number
9000-83-3
NCBI Gene ID
2246
Swiss Prot
P05230
Accession Number
NP_000791
Tag
Tag free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Growth Factors
Purity
>98% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
15.8 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Fibroblast growth factor 1 (acidic)
NCBI Organism
Homo sapiens
Background Reference 01
Powers, C.J. et al., 2000, Endocr Relat Cancer 7, 165-97.
Background Reference 02
Prudovsky, I. et al., 2003, J Cell Sci 116, 4871-81.
Background Reference 03
Ornitz, D.M. and Itoh, N., 2001, Genome Biol 2, REVIEWS3005.
Background Reference 04
Mohammadi, M. et al., 2005, Curr Opin Struct Biol 15, 506-16.
Other Product Names
FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
