Gremlin Recombinant Protein
Product Specifications
Background
Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
CAS Number
9000-83-3
NCBI Gene ID
26585
Swiss Prot
O60565
Accession Number
NP_037504
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Chemokines & Cytokines, Growth Factors
Buffer
PBS, pH7.4 with 1 mM EDTA
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
20.2 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Gremlin-1 isoform 1 precursor
NCBI Organism
Homo sapiens
Background Reference 01
McMahon R., et al., 2000, J. Biol. Chem. 275:9901-9904.
Background Reference 02
Topol L.Z., et al., 2000, Cytogenet. Cell Genet. 89:79-84.
Background Reference 03
Jaeger E., et al., 2012, Nat. Genet. 44:699-703.
Other Product Names
GREM1, CKTSF1B1, DAND2, DRM, PIG2
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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