Glypican 2 / GPC2 Recombinant Protein
Product Specifications
Background
Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
NCBI Gene ID
71951
Swiss Prot
Q8BKV1
Accession Number
NP_766000.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-322
Calculated Molecular Weight
60.6 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.6 kDa. The protein migrates as 60-106 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Glypican 2 (cerebroglycan)
NCBI Organism
Mus musculus
Background Reference 01
Herndon ME, et al. 1999. Glycobiology. 9 (2) :143-55.
Background Reference 02
Li N, et al. 2017. Proc Natl Acad Sci U S A. 114 (32) :E6623-E6631.
Background Reference 03
Bosse KR, et al. 2017. Cancer Cell. 32 (3) :295-309.
Other Product Names
Glypican 2, GPC2
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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