Canine GITR / TNFRSF18 Recombinant Protein
Product Specifications
Background
Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
CAS Number
9000-83-3
NCBI Gene ID
606971
Accession Number
NP_001177673.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Chemokines & Cytokines, Immunology
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
15.8 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
TNF receptor superfamily member 18
NCBI Organism
Canis lupus familiaris
Background Reference 01
Tuyaerts S., et al., 2007, J. Leukoc. Biol. 82:93-105.
Background Reference 02
Chattopadhyay K., et al., 2007, Proc. Natl. Acad. Sci. U.S.A. 104:19452-19457.
Other Product Names
AITR, GITR, TNFRSF18, CD357
Tested Applications
ELISA, WB
Species
Dog
Physical Properties
Lyophilized
Curated Selection
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