Coagulation Factor III / Tissue Factor Recombinant Protein
Product Specifications
Background
Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F) VII/FVIIa. In addition to full-length TF, an alternative spliced (as) form of TF can be generated that lacks the transmembrane domain and is released fromcells. In contrast to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells around blood vessels, such as adventitial fibroblasts, and body surfaces, such as epithelial cells, and plays a critical role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, particularly adenocarcinomas, express high levels of TF. A high level of tumor TF expression is associated with poor prognosis in many types of cancers, including breast, prostate, colorectal, and pancreatic cancer.
CAS Number
9000-83-3
NCBI Gene ID
2152
Swiss Prot
P13726
Accession Number
NP_001984.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-146
Calculated Molecular Weight
26.7 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.7 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Coagulation factor III, tissue factor
NCBI Organism
Homo sapiens
Other Product Names
Coagulation Factor III, Tissue Factor, TF, F3, CD142
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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