FOLR2 Recombinant Protein
Product Specifications
Background
Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
NCBI Gene ID
2350
Swiss Prot
P14207
Accession Number
P14207-1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology, Obesity, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-326
Calculated Molecular Weight
26 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Folate receptor 2 (fetal)
NCBI Organism
Homo sapiens
Background Reference 01
Ratnam, M. et al., 1989, Biochemistry, 28 (20) :8249-54.
Background Reference 02
Ross, J.F. et al., 1999, Cancer, 85:348.
Background Reference 03
Reddy, J.A. et al., 1999, Blood, 93:3940.
Background Reference 04
Ross, J.F. et al.,1994, Cancer 73:2432.
Other Product Names
FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, FBP
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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