FKBP25 Recombinant Protein
Product Specifications
Background
FKBP3 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
NCBI Gene ID
2287
Swiss Prot
Q00688
Accession Number
Q00688
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 1mM DTT,10% glycerol . It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-276
Calculated Molecular Weight
27.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
FK506 binding protein 3
NCBI Organism
Homo sapiens
Other Product Names
Peptidyl-prolyl cis-trans isomerase FKBP3, PPIase FKBP3, 25 kDa FK506-binding protein, 25 kDa FKBP, FKBP-25, FK506-binding protein 3, FKBP-3, Immunophilin FKBP25, Rapamycin-selective 25 kDa immunophilin, Rotamase, FKBP25, FKBP3
Species
Human
Physical Properties
Liquid
CAS Number
9000-83-3
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