FcRn & B2M Heterodimer Recombinant Protein
Product Specifications
Background
FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51 (alpha chain) and Beta-2-microglobulin (Beta chain) . The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk, Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog (FcRn) and beta-2-microglobulin (B2M) .
CAS Number
9000-83-3
NCBI Gene ID
2217
Swiss Prot
P55899, P61769
Accession Number
P55899, P61769
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of 50mM HEPES,150mM Nacl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
41.4 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Fc fragment of IgG receptor and transporter
NCBI Organism
Homo sapiens
Other Product Names
IgG receptor FcRn, Neonatal Fc receptor, FCRN
Species
Human
Physical Properties
Lyophilized
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