ErbB2 Recombinant Protein

Product Specifications

Background

ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.

CAS Number

9000-83-3

NCBI Gene ID

24337

Swiss Prot

P06494

Accession Number

P06494

Tag

C-6 His tag

Type

Recombinant Proteins

Source

E. coli

Buffer

Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl, 4M Urea, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

29.3 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Erb-b2 receptor tyrosine kinase 2

NCBI Organism

Rattus norvegicus

Other Product Names

Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD340, ERBB2., Her2