ErbB2 Recombinant Protein
Product Specifications
Background
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.
NCBI Gene ID
24337
Swiss Prot
P06494
Accession Number
P06494
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl, 4M Urea, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-224
Calculated Molecular Weight
29.3 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Erb-b2 receptor tyrosine kinase 2
NCBI Organism
Rattus norvegicus
Other Product Names
Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD340, ERBB2., Her2
Species
Rat
Physical Properties
Lyophilized
CAS Number
9000-83-3
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