EpCAM Recombinant Protein
Product Specifications
Background
EpCAM is also known as CO171A, ; EGP; EGP40; GA7332; KSA; M4S; MIC18; MK1; TROP1; hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
NCBI Gene ID
677680
Swiss Prot
Q1WER1
Accession Number
NP_001035118.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-270
Calculated Molecular Weight
28.2 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Epithelial cell adhesion molecule
NCBI Organism
Macaca mulatta
Background Reference 01
Linnenbach, et al., 1993, Mol Cell Biol 13 (3) : 1507–15.
Background Reference 02
Akita H, et al., 2011, Oncogene.
Background Reference 03
Winter MJ, et al., 2007, Mol Cell Biochem. 302 (1-2) :19-26.
Background Reference 04
Schmidt M, et al., 2011, Breast Cancer Res Treat. 125 (3) :637-46.
Other Product Names
EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1/4, KSA, M4S1, MIC18, MK1
Tested Applications
WB
Species
Rhesus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
FAB7169MFV500 0.1 mL
Mouse Monoclonal STING/TMEM173 Antibody (723505) [mFluor Violet 500 SE]
Ask
View Details