EpCAM Recombinant Protein
Product Specifications
Background
EpCAM is also known as CO171A, EGP, EGP40, GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A (mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
CAS Number
9000-83-3
NCBI Gene ID
17075
Swiss Prot
Q99JW5
Accession Number
AAH05618.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>98% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
28.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Epithelial cell adhesion molecule
NCBI Organism
Mus musculus
Background Reference 01
Linnenbach, et al., 1993, Mol Cell Biol 13 (3) : 1507–15.
Background Reference 02
Akita H, et al., 2011, Oncogene.
Background Reference 03
Winter MJ, et al., 2007, Mol Cell Biochem. 302 (1-2) :19-26.
Background Reference 04
Schmidt M, et al., 2011, Breast Cancer Res Treat. 125 (3) :637-46.
Other Product Names
EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1/4, KSA, M4S1, MIC18, MK1
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized
Curated Selection
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