DR6 Recombinant Protein

DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.

Contains PBS. Reconstitute with 50 μ l sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.