DNAM-1 Recombinant Protein
Product Specifications
Background
DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
CAS Number
9000-83-3
NCBI Gene ID
10666
Swiss Prot
Q15762-1
Accession Number
NP_006557
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
27.9 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
CD226 antigen isoform a precursor
NCBI Organism
Homo sapiens
Background Reference 01
Shibuya A., et al.,1995, Immunity 4:573-581.
Background Reference 02
Tahara-Hanaoka S., et al .,2003, Int. Immunol. 16:533-538.
Background Reference 03
Pende D., et al.,2004, Mol. Immunol. 42:463-469.
Other Product Names
DNAM1, CD226, PTA1
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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