DIABLO Recombinant Protein
Product Specifications
Background
Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP), DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
NCBI Gene ID
56616
Swiss Prot
Q9NR28
Accession Number
NP_063940
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Purity
>95% as determined by SDS-PAGE.
Buffer
20 mM Hepes, 150 mM Nacl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-235
Calculated Molecular Weight
21.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Diablo, IAP-binding mitochondrial protein
NCBI Organism
Homo sapiens
Background Reference 01
Du C., et al., 2000, Cell 102:33-42.
Background Reference 02
Fu J., et al., 2003, J. Biol. Chem. 278:52660-52672
Background Reference 03
Ma L., et al., 2006, Cell Death Differ. 13:2079-2088.
Other Product Names
DIABLO, SMAC
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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