Deoxycytidine Kinase Recombinant Protein
Product Specifications
Background
Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA) . DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. DCK is clinically important because of its relationship to drug resistance and sensitivity.
CAS Number
9000-83-3
NCBI Gene ID
1633
Swiss Prot
P27707
Accession Number
P27707
Tag
N-6 His, T7 tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Homeostasis, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
34 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Deoxycytidine kinase
NCBI Organism
Homo sapiens
Other Product Names
Deoxycytidine Kinase, dCK
Species
Human
Physical Properties
Liquid
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