DLL3 Recombinant Protein

Product Specifications

Background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

CAS Number

9000-83-3

NCBI Gene ID

10683

Swiss Prot

Q9NYJ7

Accession Number

NP_058637.1

Tag

Fc Tag

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Other

Purity

>90% as determined by SDS-PAGE.

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

75.0 kDa

Applications Notes

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 75.0 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

NCBI Official Name

Delta like canonical Notch ligand 3

NCBI Organism

Homo sapiens

Background Reference 01

Tanaka K., et al. 2018, Lung Cancer., 115, 116-120.

Background Reference 02

Laura R. Saunders., et al. 2015, Sci Transl Med., 26, 7 (302) .

Background Reference 03

Zhang J., et al. 2017, Oncol Lett., 13 (6), 4533-4539.

Other Product Names

Delta3, delta-like 3 (Drosophila), delta-like protein 3, DLL3, Pudgy, SCDO1, SCDO1delta3

Tested Applications

ELISA, WB

Species

Human

Physical Properties

Lyophilized

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