Cathepsin D Recombinant Protein
Product Specifications
Background
CTSD localizes to the lysosome and consists of a light chain and a heavy chain. CTSD is expressed in epithelial cells as well as in macrophages.CTSD is a lysosomal aspartyl protease that depends critically on protonation of its active site Asp residue and gets activated at pH 5 in endosome of hepatocytes. It has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix and xonnective tissue. In addition, CTSD has been used as a breast cancer tumor marker.
CAS Number
9000-83-3
NCBI Gene ID
13033
Swiss Prot
P18242
Accession Number
P18242
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM MES,150mM NaCl, pH5.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
43.9 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Cathepsin D
NCBI Organism
Mus musculus
Other Product Names
Cathepsin D, CTSD, CPSD, CSTD
Species
Mouse
Protein ID
325652083
Physical Properties
Lyophilized
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