IgG1 Fc Recombinant Protein
Product Specifications
Background
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport) . IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Tag
Flag Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Other
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-265
Calculated Molecular Weight
27.1 kDa
Applications Notes
This protein carries a flag tag at the C-terminus. The protein has a calculated MW of 27.1 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Medinger M, Tzankov A, et al. (2010), J Clin Immunol. 30 Suppl 1:S9-14.
Other Product Names
IgG1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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