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IgG1 Fc Region Recombinant Protein

Product Specifications

Background

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport) . IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.

CAS Number

9000-83-3

Accession Number

AAK53870.1

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Infectious Disease

Purity

>95% as determined by SDS-PAGE.

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

24.3 kDa

Applications Notes

This recombinant protein can be used for WB. For research use only.

Background Reference 01

Medinger M, Tzankov A, et al. (2010), J Clin Immunol. 30 Suppl 1:S9-14.

Tested Applications

WB

Species

Mouse

Physical Properties

Lyophilized

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