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IgG1 Fc Recombinant Protein

Product Specifications

Background

Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport) . IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.

CAS Number

9000-83-3

NCBI Gene ID

3500

Swiss Prot

P01857

Accession Number

AAC82527.1

Tag

Tag free

Type

Recombinant Proteins

Source

HEK293 cells

Purity

>95% as determined by SDS-PAGE.

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

26 kDa

Applications Notes

This recombinant protein can be used for WB. For research use only.

NCBI Official Name

Immunoglobulin heavy constant gamma 1

NCBI Organism

Homo sapiens

Background Reference 01

Medinger M, Tzankov A, et al. (2010), J Clin Immunol. 30 Suppl 1:S9-14.

Tested Applications

WB

Species

Human

Physical Properties

Lyophilized

Frequently Asked Questions

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