Cornulin Recombinant Protein

Product Specifications

Background

Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA) -induced apoptotic cell death and release of calcium. When Cornulin is overexpressed in oral squamous carcinoma cell lines, it regulates negatively cell proliferation by the induction of G1 arrest.

CAS Number

9000-83-3

NCBI Gene ID

49860

Swiss Prot

Q9UBG3

Accession Number

Q9UBG3

Tag

N-6 His tag

Type

Recombinant Proteins

Source

E. coli

Buffer

Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

17.45 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Cornulin

NCBI Organism

Homo sapiens

Other Product Names

Cornulin, 53 kDa Putative Calcium-Binding Protein, 53 kDa Squamous Epithelial-Induced Stress Protein, 58 kDa Heat Shock Protein, Squamous Epithelial Heat Shock Protein 53, Tumor-Related Protein, CRNN, C1orf10, DRC1, PDRC1, SEP53