Complement component C8 gamma Recombinant Protein
Product Specifications
Background
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.
NCBI Gene ID
733
Swiss Prot
P07360
Accession Number
P07360
Tag
N-6 His tag
Type
Recombinant Proteins
Source
E. coli
Buffer
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-260
Calculated Molecular Weight
22.6 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Complement component 8, gamma polypeptide
NCBI Organism
Homo sapiens
Other Product Names
Complement component C8 gamma chain, C8G
Species
Human
Protein ID
767983919
Physical Properties
Liquid
CAS Number
9000-83-3
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