CD74 Recombinant Protein
Product Specifications
Background
Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii) . CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
NCBI Gene ID
972
Swiss Prot
P04233
Accession Number
NP_004346.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Obesity, Signal Transduction, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-110
Calculated Molecular Weight
19.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD74 molecule, major histocompatibility complex, class II invariant chain
NCBI Organism
Homo sapiens
Background Reference 01
Cresswell P., 1994, Annu. Rev. Immunol. 12: 259–93.
Background Reference 02
Charest A., et al., 2003, Genes Chromosomes Cancer 37:58-71.
Background Reference 03
Leng L., et al., 2003, J. Exp. Med. 197:1467-1476.
Other Product Names
CD74, DHLAG, HLADG, II, Ia-GAMMA, p33, CLIP, INVG34
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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