CLEC12A / MICL / CLL-1 Recombinant Protein
Product Specifications
Background
CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
CAS Number
9000-83-3
NCBI Gene ID
160364
Swiss Prot
Q5QGZ9
Accession Number
NP_612210.4
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
50.2 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 50.2 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
C-type lectin domain family 12 member A
NCBI Organism
Homo sapiens
Background Reference 01
Toft-Petersen M, et al. 2016. Br J Haematol. 175 (3) :393-401.
Background Reference 02
Neumann K, et al. 2014. Immunity. 40 (3) :389-99.
Background Reference 03
Chen CH, et al. 2006. Blood. 107 (4) :1459-67.
Other Product Names
CLEC12A, MICL, CLL-1, CLL1, DCAL2, DCAL-2, CD371
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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