CD59 Recombinant Protein
Product Specifications
Background
CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL. CD59 has been identified as a glycosylphosphatidylinositol-anchored membrane protein that acts as an inhibitor of the formation of the membrane attack complex to regulate complement activation. Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-232
Calculated Molecular Weight
10.8 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.8 kDa. The protein migrates as 15-18 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Zhang R, et al. Future Oncol. 2018. 14 (8) :781-791.
Background Reference 02
Höchsmann B, et al. Hematol Oncol Clin North Am. 2015. 29 (3) :495-507.
Background Reference 03
Fülöp G, et al. Biomolecules. 2018. 8 (2) .
Other Product Names
CD59,16.3A5,1F5, EJ16, EJ30, EL32, FLJ38134, FLJ92039, G344, HRF20, MAC-IP, MACIF, MEM43, MGC2354, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, Protectin
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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