CD45 / PTPRC Recombinant Protein
Product Specifications
Background
CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.
CAS Number
9000-83-3
NCBI Gene ID
5788
Swiss Prot
P08575
Accession Number
NP_002829.3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Infectious Disease, Neuroscience
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
62.8 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 62.8 kDa. The protein migrates as 120-170 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
ProteintyrosinephosphatasereceptortypeC
NCBI Organism
Homo sapiens
Background Reference 01
Shen F.W. et al. Immunogenetics 24 (1986) 146–149.
Background Reference 02
Charbonneau H. et al. Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 7182–7186.
Background Reference 03
Rheinländer A. et al. Immunol Lett. 2018 Apr; 196:22-32.
Other Product Names
CD45, PTPRC, L-CA, T200
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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