CD40 Recombinant Protein
Product Specifications
Background
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
NCBI Gene ID
958
Swiss Prot
Q9UBH0
Accession Number
P25942
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Immunology, Neuroscience, Signal Transduction, Stem Cell, Other
Concentration
1mg/ml after reconstitution.
Buffer
Contains PBS. Reconstitute with 50 μ l sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-269
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
CD40 molecule, TNF receptor superfamily member 5
NCBI Organism
Homo sapiens
Other Product Names
Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5, CD40L Receptor
Species
Human, Mouse
Protein ID
4507581
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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